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Master Thesis Research Project

Cell death and immunity in the lung disease COPD

02.05.2024

Master Thesis Research Project

AG Conlon/Yildirim – LHI/CPC Helmholtz Munich Neuherberg

Cell death and immunity in the lung disease COPD


Have you ever heard about COPD?
Chronic obstructive pulmonary disease is a chronic lung disease. It is the third most common cause of death! Especially after COVID-19, everyone is aware of how important it is to have a healthy lung.
Our group is part of the Institute of Lung Health and Immunity (LHI) at the Helmholtz Munich. Our main goal is to better understand how our lungs work, especially under challenging conditions. Our focus is the understanding of how immune cells contributes to the disease development and progression in particular in COPD. We published recently Ferroptosis, a newly discovered type of cell death to occur in lung epithelial cells of COPD patients and smoked mice1. We would like to better understand the exact underlying mechanism and the pathway regulating genes involved in COPD.

  • You are interested in immunology and disease-related mechanisms?
  • You want to better understand one of the most interesting organs in the body, the lung?
  • You want to practice already gained knowledge and are motivated to learn more methods?

Then you are the perfect candidate for us! And here is what we offer you:

  • You will be able to investigate a quite newly described type of cell death, called ferroptosis in the context of COPD!
  • You will work in the lab using interesting techniques (WB, qPCR, FACS, cell culture including lipidperoxidation and cell viability readouts)!
  • You will be perfectly guided by your direct supervisor (Postdoc) that always has time for you!

You think this is the best opportunity to finish your masters or to gain new experience in a long-term practical course? Then feel free to contact us: Dr. Aicha Jeridi: aicha.jeridi@helmholtz-munich.de.

1 Gunes Gunsel, G. et al. The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD. Nat Commun 13, 1303, doi:10.1038/s41467-022-28809-4 (2022).